It is fine to have creative or personalized email addresses, but use your judgement, e.g. sexybaby@hotmail.com is probably not suitable for professional communications.
If you have multiple email accounts which you cannot check with sufficient frequency, just set automatic forwarding to a single (default) account. You can also setup (e.g. via SMTP) that single default account to reply on behalf of the other aliases.
If you do not intend to use a particular email account, disable or delete it so that people would not expect reply from there.
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