I bumped into this interesting and concise article a few days ago. I encourage you to read it in whole and watch the embedded video.
Basically, it echoes my personal experiences quite well, across product groups, industry labs, and academia. For jobs that require any dose of innovation, the success predominantly depends on individual creativity, perseverance, and autonomy, rather than knowledge, smartness, or even intelligence.
I have a very simple rule of thumb to know, at an early stage, whether a student is suitable for research, or any form of innovative work. It is a bit like push and pull. If I push you a bit (e.g. suggesting you to try an experiment) and you can react back with at least something I did not know a priori (e.g. a surprising result or a better way to do that experiment), you are probably good. Otherwise, you are just a robot that needs to be told exactly what to do. It is a bit better, but not fundamentally different from, say, strawberry pickers or assembly line workers.
Autonomy is the main distinction between jobs in the past 2 millenniums (e.g. agriculture, manufacturing) and this new millennium (the so called knowledge economy). It is also the main reason behind the bifurcation of economic power, social class, and a lot of other things.
On a related note, a recent story deeply touched my heart. A previous unknown, 50+ years old mathematician, with stints in fast food restaurants, recently proved an elusive property of prime numbers that has been one of the longest standing math challenges.
I did not know this guy, but I bet he must have a tremendous amount of passion and perseverance to spend all the time and efforts to pull this off.